Glaucoma
Conditions
Keywords
intraocular pressure, contrast sensitivity, visual function
Brief summary
During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.
Detailed description
Primary open angle glaucoma patients without use of antiglaucoma medications will be enrolled in this study. After inclusion, the patients will randomly receive one of three antiglaucoma medications (timolol maleate 0,5%, brimonidine tartrate 0,2% or travoprost 0,004%) in one randomly selected eye. The patients will be evaluated with Goldmann applanation tonometry, visual acuity test, contrast sensitivity test, visual quality perception test (visual analogue scale) and standard automated perimetry before and after 4 weeks of glaucoma treatment onset.
Interventions
DRUGtimolol maleate 0,5%
DRUGbrimonidine tartrate 0,2%
DRUGtravoprost 0,004%
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Primary open angle glaucoma * Intraocular pressure greater than 21 mmHg
Exclusion criteria
* Best corrected visual acuity (BCVA) worse than 20/80 * Significant media opacity * History of steroid use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraocular pressure | — |
| contrast sensitivity | — |
| visual quality perception | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean deviation of the visual field (MD) | — |
| Pattern Standard Deviation of the visual field (PSD) | — |
| visual acuity | — |
Outcome results
None listed