Morbid Obesity
Conditions
Keywords
Morbid obesity, Bariatric Surgery, Obesity Surgery, Omentectomy, Sleeve gastrectomy
Brief summary
* The investigators aim to determine the clinical and metabolic effects of sleeve gastrectomy with or without omentectomy in the treatment of morbid obesity. * The investigators hypothesize that the endocrine suppression of ghrelin (appetite hormone)and resistin (insulin antagonist) provided by sleeve gastrectomy and omentectomy (omentum or intra-abdominal fat removal) will provide clinical and metabolic benefits for morbidly obese patients.
Detailed description
This is a phase 3 prospective randomized trial.
Interventions
PROCEDURELaparoscopic restrictive procedure
Patients will receive laparoscopic sleeve gastrectomy with or without omentectomy
PROCEDURESleeve gastrectomy
Sleeve gastrectomy
Sponsors
North Texas Veterans Healthcare System
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Morbidly obese VETERANS ONLY (BMI\>35 with comorbidities or BMI\>40) * Age \> 18
Exclusion criteria
* Pregnancy * Uncontrolled medical or psychiatric conditions * Previous bariatric procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weight loss | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic outcomes | 5 years |
| Diabetes resolution | 5 years |
Countries
United States
Outcome results
None listed