Gravidity, Labor Onset
Conditions
Brief summary
The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.
Detailed description
During the past years there has been a conflict between different studies regarding the correlation between intercourse during pregnancy and early labor. Brustman et al showed that women that were at a high risk for early delivery and had intercourse and then an early labor had significantly increase uterine activity compared to women at low risk. Petridou et al showed that this risk is significantly higher at week 33 of gestation. However, the Cochrane Library summary leaves the question of correlation between intercourse and early labor unanswered. In Sayle et al's study showed no correlation between early delivery and intercourse. In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene. These polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma. Since this gene is also expressed in the uterine muscles we wanted to determine whether there is a correlation between the three polymorphisms T-549C, C-441T, T-197C, G+1044A and early delivery due to intercourse. 1. Brustman LS, Raptoulis M. Langer O, Anyaegbunam A & Merkatz IR. Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor. Obstet Gynecol 1989;73:166-168 2. Petridou E, Salvnos H, Skalkidou A, Dessypris N, Moustaki M & Trichopoulos D. Are there common triggers of preterm deliveries. British J Obst Gynecol 2001;108:598-604) 3. Kavanagh J, Kelly AJ & Thomas J. Sexual intercourse for cervical ripening and induction of labour. The Cochrane Database of Systematic Reviews 2001, Issuse 2.Art. No.:CD003093. DOI: 10.1002/14651858.CD003093 4. Sayle AE, Savitz DA, Thorp JM, Hertz-Picciotto I & Wilcox AJ. Sexual activity during late pregnancy and risk of preterm delivery. Obstet Gynecol 2001;97:283-9) 5. Bernal AL. Mechanisms of labour-biochemical aspects. BJOG 2003;110(Supp 20):39-45 6. Oguma T, Palmer L, Birden E, Sonna LA, Asano K& Lilly CM. Role of prostanoid dp receptor variants in susceptibility to asthma. NEJM 2004;351:1752-63
Interventions
BEHAVIORALCorrelation between early delivery and coital activity
Sponsors
Shaare Zedek Medical Center
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 40 Years
Inclusion criteria
* Women who start delivery in weeks 23-35 of pregnancy 12 hours after intercourese. * Women who come for delivery after week 31 and have not had intercourse during the previous month. * Women at term who have been sexually active during their pregnancy.
Exclusion criteria
* Any other women who come in for delivery.
Countries
Israel
Contacts
Primary ContactMichael Schimmel, Prof.
Outcome results
None listed