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Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.

Changes in Different Fat Compartments During Weight Loss and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00431587
Enrollment
1000
Registered
2007-02-06
Start date
2007-06-30
Completion date
Unknown
Last updated
2008-04-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Syndrome, Morbid Obesity, Visceral Obesity

Keywords

morbid obesity, metabolic syndrome, visceral fat, peripheral fat

Brief summary

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic improvements. The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments, and their effect on the improvement of the metabolic profile. In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery

Detailed description

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern. The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments. Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity. It has been previously shown, and it was also partially confirmed in this study, that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels. This again suggests a threshold of proportional visceral fat loss, above which there is an improvement in insulin sensitivity and other component of metabolic syndrom. We will quantify the different fat compartments changes after bariatric surgery by means of CT scan.

Interventions

None listed

Sponsors

Hadassah Medical Organization
Lead SponsorOTHER

Study design

Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Morbid obesity, * Metabolic syndrome

Exclusion criteria

* Previous abdominoplasty surgery, * Previous major abdominal surgey

Countries

Israel

Contacts

Primary ContactAndrei Keidar, MD
andreik@hadassah.org.il00 972 2 6777384

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026