Nicotine Dependence, Nicotine Use Disorder, Smoking, Tobacco Use Disorder
Conditions
Keywords
Nicotine Dependence, Smoking, Tobacco Use Disorder, Nicotine Use Disorder
Brief summary
This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among young women. Nicotine has short- term, facilitating effects on attention and response inhibition. Therefore, individuals who are impaired on cognitive functions such as these and initiate cigarette smoking may be more likely to maintain the habit and develop nicotine dependence. The research protocol specifically tests whether administration of nicotine to non-abstinent, regular cigarette smokers improves cognitive function in those domains where the participants had previously been shown to manifest performance deficits
Interventions
DRUGNicotine
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
DOUBLE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Reported smoking cigarettes on a daily basis at the time of the original study and continue to smoke currently * Manifested poor performance on the MFFT (The neurocognitive test that yielded differences between smokers and non-smokers) * Competent and willing to give written informed consent
Exclusion criteria
* Pregnancy, breast-feeding, non-use of contraception such that the possibility of pregnancy cannot be excluded * Intake of any medication that may potentially interact with nicotine. * Any current or past medical condition that represents a contra-indication to nicotine administration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurocognitive functions | — |
Countries
Israel
Contacts
Primary ContactAvi Yakir, MD
Backup ContactHadas Lemberg, PhD
Outcome results
None listed