Pharmacological Modulation of the Intrarenal Pressure During Endourological Procedures in the Upper Urinary Tract

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00428428

Enrollment

Registered

2007-01-30

Start date

2007-02-28

Completion date

2007-11-30

Last updated

2007-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney Stone, Unexplained Haematuria, Benignant Tumour Mass in the Upper Urinary Tract

Keywords

kidney stone, ureteroscopy

Brief summary

The purpose of the study is to examine the effect of endoluminally administrated isoproterenol on pelvic pressure increase during flexible ureterorenoscopy in 14 humans. We propose that isoproterenol has potential of reducing intrarenal pressure during ureterorenoscopies. Lower intrarenal pressures may have the advantage of facilitating the procedure and reducing intraoperative complications as bleeding and infections.

Interventions

DRUGIsoproterenol

ISO 0.1 microgram/ml, 8 ml/min irrigation compared to saline irrigation

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Indication for ureterorenoscopy * Age\> 18 years * Normal blood pressure

Exclusion criteria

* Malignant disease in the upper urinary tract * Heart disease * Allergy to Isoproterenol * Use of α-blocking or β-blocking medicine * Use of Calcium-antagonists * Use of NSAIDs the last 48 hours * Present stone or JJ-stent in the ureter * Neurologic disease in the bladder * Pregnancy * Nursing mothers

Design outcomes

Primary

Measure	Time frame
pelvic pressure	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026