Asthma, Bronchopulmonary Dysplasia, Infant, Premature
Conditions
Keywords
Infant, Premature, Bronchopulmonary Dysplasia, Asthma
Brief summary
The purpose of this study is to evaluate how easily gas can be taken up by the lung. We are comparing infants born premature \<32 weeks gestation to infants born full term \>37 weeks. We hope to evaluate the differences between the two groups in order to learn more about premature lung growth and development.
Detailed description
We hypothesize that infants who were born prematurely but are clinically without chronic respiratory disease have a lower lung diffusion capacity than healthy infants born at full term, when evaluated at comparable post-conception ages. In addition, prematurely born infants that develop chronic lung disease have an even lower diffusion capacity than healthy premature infants and full term infants. A lower diffusion capacity, when normalized to lung volume, would be consistent with decreased alveolarization and alveolar surface area in the infants born prematurely. We will study the age range of 1 to 24 month as this represents the period of rapid lung growth.
Interventions
None listed
Sponsors
Indiana University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Months to 2 Years
Healthy volunteers
No
Inclusion criteria
* Group 1 Infants born at \< 32 weeks gestation with Chronic lung disease * Group 2 Infants born at \<32 weeks gestation without Chronic lung disease * Group 3 Infants born full term at \>37 weeks
Exclusion criteria
* Group 1 and Group 2--No heart disease, no oxygen requirement * Group 3--No hospitalization for respiratory illness, No asthma, No heart disease, No history of wheezing, asthma or treatment with asthma medications.
Countries
United States
Outcome results
None listed