Heredity of Retinal Vessel Tortuosity

Heredity of Retinal Vessel Tortuosity - A Twin Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00427063

Enrollment

218

Registered

2007-01-26

Start date

1998-01-31

Completion date

1998-12-31

Last updated

2007-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retinopathy of Prematurity

Keywords

retinal vessels, tortuosity

Brief summary

The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years. We expect to find a high heredity for the variation in tortuosity. This knowledge can contribute to the elucidation of the pathology in retinal diseases.

Detailed description

All persons underwent an ophthalmic examination including refraction, slit lamp biomicroscopy and digital fundus photography. Two independent graders (both with an MD degree) made a visual grading of the severity of tortuosity of the retinal arterioles in the fundus images.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

20 Years to 46 Years

Healthy volunteers

Yes

Inclusion criteria

* Samesex twin pairs of self-assessed good health

Exclusion criteria

* Diabetes mellitus * Hypertension * Thyroid disease * Cataract or other opacities of the refractive media * Missing fundus photographs

Countries

Denmark

Outcome results