Orthostatic Hypotension, Spinal Cord Injury
Conditions
Keywords
Blood pressure, Orthostatic hypotension, Spinal Cord Injury, Sympathetic vascular control, Midodrine
Brief summary
With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure. These hemodynamic alterations stimulate the baroreceptor reflex, which is mediated via the central nervous system to increase peripheral sympathetic vasomotor tone, restoring blood pressure and cardiac output within seconds-to-minutes of the assumption of the upright position. Following SCI, individuals often experience the inability to adjust to postural changes due to disruption of central command of the baroreceptor reflex and reduction in efferent sympathetic neural pathways; consequently, orthostatic hypotension (OH) and symptoms of cerebral hypo-perfusion may ensue. OH is a well-documented phenomenon, which is characterized by a fall in systolic blood pressure of \>20 mmHg or diastolic BP of \> 10 mmHg within 3 minutes of assumption of an upright posture. As a consequence of OH, many individuals experience symptoms of cerebral hypo-perfusion which include lightheadedness, dizziness, blurry vision, fatigue, nausea, ringing in the ears, cognitive impairment and heart palpitations. Although several investigators have reported increased prevalence of OH during the acute phase of spinal cord injury (SCI), individuals with chronic injury also experience significant falls in blood pressure with seated upright postures. This investigation will examine the effects of an alpha-agonist, midodrine hydrochloride, during head-up tilt on systemic blood pressure, cerebral blood flow and cerebral oxygenation compared to placebo administration in persons with chronic SCI who demonstrate significant orthostatic hypotension during a 24-hour observation study. This is the first study to determine the dose response and efficacy of midodrine to improve orthostatic blood pressure and cerebral blood flow and oxygenation in the SCI population.
Detailed description
In individuals with SCI, blood pressure regulation is altered compared to the non-SCI population and relates to the degree of sympathetic vascular denervation. The inadequate release of norepinephrine with postural change is a primary component of OH and several reports have documented significantly reduced plasma norepinephrine levels in individuals with tetraplegia. Ephedrine sulfate and midodrine hydrochloride, both 1 receptor agonists, are recommended for the treatment of postural hypotension in this population. Although there are case reports documenting improved blood pressure regulation in persons with SCI treated with an 1 receptor agonist, this pharmacological treatment for OH has not been adequately studied in this population. A dose response trial will be used to determine the efficacy of midodrine hydrochloride (5 and 10 mg) compared to no drug at improving systemic blood pressure, cerebral blood flow and oxygenation and at reducing symptomatic hypotension during tilt-table testing in 16 individuals with SCI who manifest significant orthostatic hypotension (total time \[minutes\] spent with hypotension \[ 20% fall in mean arterial pressure from supine laboratory observation\] over a 24-hour observation. Subjects will receive, in an increasing dose manner and on separate days: no drug, 5 and 10 mg of oral midodrine hydrochloride. Oral ingestion of the pill (placebo or midodrine) will be at 30 minutes during the 60 minute supine rest period prior to the head-up tilt maneuver. A progressive head-up tilt will be utilized in which the table will be adjusted to 15 , 25 , 35 for 5 minutes at each angle and then will be maintained at 45 for 45 minutes or until the subjects experiences symptoms of compromised cerebral blood flow, which include, but are not limited to, light headedness, blurry vision, dizziness and nausea. Throughout each test day, measurements of heart rate, blood pressure, middle cerebral blood flow velocity, and cerebral oxygenation will be obtained. In addition, blood draws will be completed to capture humoral factors responsible for blood pressure regulation.
Interventions
Alpha1-agonist, exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure.
Sponsors
James J. Peters Veterans Affairs Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* This study will be performed on subjects 18 to 65 years old, with chronic SCI (\> 1 year), who are neurologically stable and have demonstrated significant hypotension (total time \[proportion 50%\] spent with hypotension \[systolic BP below 110 mmHg for males and 100 mmHg for females\] during a 24-hour observation.
Exclusion criteria
* hypertension * diabetes * vascular disease * cardiac disease * cardiovascular medication * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic Blood Pressure | The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position. | brachial artery systolic blood pressure (mmHg) |
Countries
United States
Participant flow
Recruitment details
2008-2010
Pre-assignment details
no subject was excluded from study participate prior to group assignment.
Participants by arm
| Arm | Count |
|---|---|
| Arm 1 Blood pressure response during HUT following administration of Midodrine Hydrochloride compared with no drug. | 11 |
| Total | 11 |
Withdrawals & dropouts
| Period | Reason | FG000 |
|---|---|---|
| Overall Study | Lost to Follow-up | 1 |
Baseline characteristics
| Characteristic | Arm 1 |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 11 Participants |
| Age, Continuous | 42 years STANDARD_DEVIATION 9 |
| Region of Enrollment United States | 11 participants |
| Sex: Female, Male Female | 2 Participants |
| Sex: Female, Male Male | 9 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 11 |
| serious Total, serious adverse events | 0 / 11 |
Outcome results
Primary
Systolic Blood Pressure
brachial artery systolic blood pressure (mmHg)
Time frame: The difference between the average supine systolic blood pressure and the average systolic blood pressure at 45 degree head-up tilt position.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| No-drug | Systolic Blood Pressure | Baseline Blood Pressure | 98 mmHg | Standard Deviation 5 |
| No-drug | Systolic Blood Pressure | Head-up Tilt Blood Pressure | 87 mmHg | Standard Deviation 15 |
| Midodrine 5 mg | Systolic Blood Pressure | Baseline Blood Pressure | 97 mmHg | Standard Deviation 5 |
| Midodrine 5 mg | Systolic Blood Pressure | Head-up Tilt Blood Pressure | 96 mmHg | Standard Deviation 19 |
| Midodrine 10 mg | Systolic Blood Pressure | Baseline Blood Pressure | 102 mmHg | Standard Deviation 12 |
| Midodrine 10 mg | Systolic Blood Pressure | Head-up Tilt Blood Pressure | 109 mmHg | Standard Deviation 22 |