Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00424957

Enrollment

Registered

2007-01-22

Start date

2006-11-30

Completion date

2008-10-31

Last updated

2009-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis, Hepatic Encephalopathy

Keywords

Ammonia, Astrocytes, Citric acid cycle, Alpha ketoglutarate dehydrogenase

Brief summary

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

45 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, * 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, * 6 healthy subjects age and sex matched

Exclusion criteria

* Neurological and/or psychiatric condition, * Non-treated diabetes, * Pregnancy/breast-feeding

Countries

Denmark

Outcome results