Asthma
Conditions
Brief summary
Montelukast (for asthma) and desloratadine (for allergies) are effective therapy for their current uses. Part of what happens when your allergies trigger your asthma should be prevented by either of these drugs. This project is being conducted to determine if these drugs are effective, either alone or in combination, on controlling asthma that is triggered by allergies.
Interventions
DRUGMontelukast (10mg) and Desloratadine (5mg)
Sponsors
University of Saskatchewan
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* baseline FEV1 \> or = 65% predicted * positive methacholine challenge (i.e. methacholine PC20 \< or = 16mg/ml * positive allergen challenge
Exclusion criteria
* negative skin prick test * lung condition/disease other than asthma * currently use montelukast and/or desloratadine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Late asthmatic response (maximum percent decrease in FEV1) | — |
Secondary
| Measure | Time frame |
|---|---|
| Early asthmatic response (maximum percent decrease in FEV1 | — |
| Changes in sputum cell/mediator content | — |
| Changes in airway hyperresponsiveness (methacholine PC20) | — |
Countries
Canada
Outcome results
None listed