Early Diagnosis of Asthma in Young Children

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00422747

Enrollment

202

Registered

2007-01-17

Start date

2007-04-30

Completion date

2012-08-31

Last updated

2013-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Keywords

asthma, transient wheezing, early diagnosis, exhaled air, nitrogen monoxide, airway resistance

Brief summary

The overall aim of the study is an early asthma diagnosis in young children by the use of non-invasive biomarkers of airway inflammation /oxidative stress in exhaled air, and early lung function measurements

Interventions

DRUGbeclomethasondipropionate

2 x 100 ug dd for two months, via aerochamber

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

2 Years to 4 Years

Healthy volunteers

Yes

Inclusion criteria

* Children aged 2-3 years, with recurrent respiratory symptoms suggestive of asthma * Children aged 2-3 years, with no or minor respiratory symptoms

Exclusion criteria

* Mental retardation * Cardiac anomalies * Congenital malformations * Other diseases of the lungs/airways * Chronic systemic inflammatory diseases like M. Crohn * The inability to perform lung function measurements and/or exhaled air collection

Design outcomes

Primary

Measure	Time frame
- definite asthma diagnosis - biomarkers in exhaled breath	6 years of age

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 2, 2026