Autonomic Nervous System Diseases, Baroreflexes, Cerebrovascular Accident
Conditions
Keywords
Ischemic stroke, Baroreflex sensitivity, Prognosis, Cardiovascular autonomic regulation
Brief summary
After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke. The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.
Interventions
None listed
Sponsors
Far Eastern Memorial Hospital
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke * 50-80 years old * Must have either brain CT or brain MRI done
Exclusion criteria
* NIHSS score \> 10 * Patient could not cooperate * Unstable vital sign * Atrial fibrillation * Transient ischemic attack patient * Diabetic patient * Impaired renal function (Cr \> 2.26 mg/dl) * Unstable angina, acute myocardiac infarction, cardiomyopathy patients * Patient who has known autonomic dysfunction
Countries
Taiwan
Contacts
Primary ContactSiupak Lee, M.D.
Outcome results
None listed