Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans

Conditions

Insulin Resistance, Obesity, Type 2 Diabetes

Keywords

insulin resistance, insulin secretion, advanced glycation end-products

Brief summary

We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade inflammation. We propose to test this hypothesis by performing euglycemic hypeinsulinemic glucose clamp and intravenous glucose tolerance test before and after low AGE diet and normal Australian diet in a cross-over design. This study will provide information relevant to the development and prevention of type 2 diabetes.

Karma Pearce, Alicia Hatzinikolas, Lisa Moran, Maximilian de Courten, Josephine M. Forbes et al. (9 authors)

International Journal of Food Sciences and Nutrition2017-05-024 citations

10.1080/09637486.2017.1319468

Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial

Barbora de Courten, Maximilian de Courten, Georgia Soldatos, Sonia Dougherty, Nora E. Straznicky et al. (14 authors)

American Journal of Clinical Nutrition2016-03-31136 citations

10.3945/ajcn.115.125427

Dietary Advanced Glycation End Products Consumption as a Direct Modulator of Insulin Sensitivity in Overweight Humans: A Study Protocol for a Double-Blind, Randomized, Two Period Cross-Over Trial

Barbora de Courten, Maximilian de Courten, Casper G. Schalkwijk, Karen Z. Walker, Josephine M. Forbes

JMIR Research Protocols2015-07-299 citations

10.2196/resprot.4552

Interventions

BEHAVIORALdietary intervention

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* weight stable overweight and obese (BMI ≥ 25kg/m2) non-diabetic individuals, aged 18-50 years and healthy according to medical history, blood biochemistry and physical examination.

Exclusion criteria

* Participants will be excluded if they: * are aged \<18 years or \> 50 years; * currently smoke, have high alcohol use; or a positive urine drug screening test; * have a history of: diabetes, cardiovascular and hematological disease, respiratory, gastrointestinal, endocrine, renal or central nervous system disease, psychosis or psychiatric disorder, active cancer within last 5 years. * are actively seeking to lose weight, or if their weight has changed by more than 10 kilograms in the previous 12 months. * have been taking medication within one month prior to commencing the study; * have acute inflammation (by history, physical or laboratory examination) * are on hormonal contraceptives, or pregnant (by HCG urine pregnancy screening test) or lactating * have highly unusual dietary habits or follow vegan diets (because of the difficulty in complying with the assigned diet). * have current diabetes (determined by history and/or 75g glucose OGTT) * are unable to provide informed consent

Countries

Australia

Outcome results

None listed