Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics

Effect of Chronic Administration of Sildenafil on Endothelial Function in Men With Diabetes

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00420901

Enrollment

Registered

2007-01-11

Start date

1999-01-31

Completion date

2000-02-29

Last updated

2007-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes

Keywords

function, inhibition

Brief summary

chronic PDE5-Inhibition improves endothelial function in diabetics

Detailed description

Evaluation of endothelial function at baseline and after chronic administration of sildenafil in male subjects with diabetes

Interventions

DRUGsildenafil

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

35 Years to 75 Years

Healthy volunteers

Inclusion criteria

* type 2 diabetes * males

Exclusion criteria

* females, nitrate use, PDE5-Inhibitors intolerance

Design outcomes

Primary

Measure	Time frame
Endothelial function responders - Improvement in endothelial function	—

Secondary

Measure	Time frame
Changes in vascular inflammatory markers	—

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026