Asthma, Bronchopulmonary Dysplasia, Infant, Premature, Diseases
Conditions
Keywords
infant, premature, Bronchopulmonary dysplasia, asthma
Brief summary
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
Detailed description
SPECIFIC AIM # 1: Determine the relationship between parenchymal tissue and alveolar volume with normal lung growth early in life We hypothesize that during the first two years of life that parenchymal surface area and alveolar volume increase with somatic growth; however, the ratio of surface area to volume remains constant, while ventilation within the lung becomes more homogenous. SPECIFIC AIM # 2: Determine the pulmonary sequelae of premature birth and assess the effectiveness of early treatment strategies upon the pulmonary sequelae. We hypothesize that premature birth impedes growth and development of the lung parenchyma and the airways at a corrected-age of 1-year. In addition, initiating continuous positive airway pressure (CPAP) and a permissive ventilatory strategy in very premature infants at birth will improve lung growth and lung function compared to treatment with early surfactant and conventional ventilation.
Interventions
None listed
Sponsors
Indiana University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Months to 24 Months
Healthy volunteers
No
Inclusion criteria
* Group 1 * full term greater than 37 weeks * Group 3 * infants born premature between 23-35 weeks of age to be tested between the ages of two to twenty four months corrected.
Exclusion criteria
* heart disease * severe developmental delays
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pulmonary function Test | day of testing | Forced Expiratory flows, single breath diffusion capacity and alveolar volume |
Countries
United States
Outcome results
None listed