Failure to Wean, Respiratory Failure, Ventilator Dependent
Conditions
Keywords
ventilator weaning, weaning, respiratory failure, inspiratory muscle strength training
Brief summary
The purpose of this study is to determine if inspiratory muscle strength training will increase the proportion of ventilator dependent patients weaned versus Sham treated patients.
Detailed description
The inspiratory muscle strength training consists of 4 sets of 6-10 breaths through a threshold inspiratory muscle strength training device, 5 days per week. The inspiratory muscle training is conducted at the highest pressure setting tolerated by the patients. The Sham groups uses an inspiratory muscle trainer that does not increase inspiratory muscle strength. Both the treated and Sham groups participate in progressively lengthening periods of breathing without ventilator as tolerated. Patients are considered weaned when they can breathe for 72 consecutive hours without any ventilator support.
Interventions
PROCEDUREinspiratory muscle strength training
Sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Failure to wean patients in the medial, surgical and intermediate respiratory care units at Shands Hospital * medically stable * able to initiate spontaneous breaths * able to provide informed consent * able to follow simple instructions
Exclusion criteria
* life expectancy \< 12 months due to malignancy * damaged phrenic nerves * neuromuscular diseases * heart or lung transplant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ventilator dependent status | — |
Secondary
| Measure | Time frame |
|---|---|
| breathing patterns during failed and passed unsupported breathing trials | — |
| maximal inspiratory pressure | — |
Countries
United States
Outcome results
None listed