The Impact of Right Ventricular Pacing on Tricuspid Regurgitation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00419354

Enrollment

Registered

2007-01-08

Start date

2007-03-31

Completion date

2010-03-31

Last updated

2009-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tricuspid Regurgitation

Keywords

Pacemaker, Tricuspid regurgitation

Brief summary

1 To examine whether right ventricular pacing has an impact on tricuspid regurgitation grade that is related to pacing rather than to valve closure interference by the electrode.

Detailed description

1 Traditionally, tricuspid regurgitation in the presence of pacemaker is attributed to the physical interference of the valve closure by the electrode. 2 Right ventricular pacing may be associated with dyssynchrony in contraction of the right ventricular wall (i.e. septum and free wall. 3 The tricuspid sub-valvar apparatus is anchored to the septum and free wall, thus may be sensitive to dyssynchrony in those wals contraction. 4 The study hypothesis is that the dyssynchrony in right ventricular contraction, induced by pacing, may increase tricuspid regurgitation grade and that this is a mechanism is independent of the mechanical effect of the electrode on the valve closure.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 years * Permanent pacemaker

Exclusion criteria

* Epicardial pacing * Left ventricular dysfunction * Organic tricuspid regurgitation * Bi-ventricular pacemaker * Atrial fibrillation * Complete pacemaker dependence

Countries

Israel

Contacts

Primary ContactMordehay Vaturi, MD

mvaturi@clalit.org.il97239376176

Outcome results