Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function

Inclusion criteria

Inclusion: * Are aged between 18-70 years, inclusive. * If Female, you must be incapable of becoming pregnant. * Show FEV1 of more than 70% of the predicted normal at screening. * Are able to correctly use a DISKUS at the screening visit. * Have Body Mass Index within the range of 19-33 kg/m2 inclusive. * Do not show a positive pre-study urine drug screen. * Do not show a positive pre-study blood alcohol test. * Demonstrate a clinically normal 12-lead ECG at screening. * Do not show a positive blood test for HIV. If you are a Healthy Volunteer you must also: * Have no significant abnormality on clinical examination. * Have Liver Function Tests within the reference range at screening. If you are a Patient Volunteer you must: * Have moderate hepatic impairment * Have no significant abnormality on clinical examination apart from hepatic impairment. Exclusion: * Suffered an upper respiratory infection in the 4 weeks before the screening visit. * Suffered a lower respiratory infection in the 6 weeks before the screening visit. * Taken oral corticosteroids in the 8 weeks before the screening visit. * Taken inhaled, intranasal or topical steroids in the 4 weeks before the screening visit. * A prolonged heartbeat (QTc interval \>470msec). * High blood pressure (systolic \>160mmHg or diastolic \>90mmHg) or as defined by the Investigator. * Known sensitivity to corticosteroids. * A history of lactose intolerance. * A history of severe milk protein allergy. * Donated blood in the last 3 months, or more than 1500mL (1000mL if female) in the last 12 months (including the amount taken for this study). * Participated in a clinical trial within the last 3 months where you are/were exposed to a drug or device.