Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2 Study)

Conditions

Cardiomyopathies, Coronary Disease, Heart Failure, Heart Valve Diseases, Left Ventricular Hypertrophy

Brief summary

Chronic Heart Failure Analysis and Registry in the Tohoku District 2 (CHART-2 Study) is a large, prospective, hospital-based cohort study to investigate the following: * Characteristics of patients with chronic heart failure and prognostic risks of these patients. * Characteristics of patients with high risk for heart failure and critical factors which predict the development of symptomatic heart failure in these patients. * The incidence and prognostic impact of metabolic syndrome in patients with chronic heart failure. * The association between metabolic syndrome and the development of symptomatic heart failure.

Detailed description

The CHART-2 Study is a multicenter prospective observational cohort study identifying the characteristics, mortality and prognostic risks of patients with overt HF and patients without HF but who are at high risk for disease progression of cardiovascular diseases (CVD). The purposes of the study are as follows: 1. to elucidate characteristics of patients with overt HF and the associated prognostic risks 2. to elucidate characteristics of patients at risk for HF and the factors associated with CVD progression 3. to elucidate factors associated with the development of AHFS 4. to elucidate prevalence and prognostic impact of metabolic syndrome (MetS) in patients with overt HF 5. to elucidate the association between MetS and the development of AHFS 6. to elucidate the prevalence and prognostic impact of malignancy in patients with CVD 7. to elucidate the prevalence of patients needing home nursing care and the characteristics of bedridden patients with CVD.

Ito T, Nochioka K, Noda T, Shiroto T, Yamanaka S, Yamamoto N, Sato H, Chiba T, Nakano M, Inoue T, Susukita K, Takahama H, Takahashi J, Miyata S, Shimokawa H, Yasuda S.

2025-09-25

10.1016/j.ijcha.2025.101812

Association of a mild or an important decline in left ventricular ejection fraction with ventricular tachyarrhythmias, sudden cardiac death, and all-cause death in heart failure with preserved ejection fraction: a report from the CHART-2 Study.

Ito T, Noda T, Nochioka K, Shiroto T, Yamamoto N, Sato H, Hayashi H, Chiba T, Nakano M, Takahama H, Takahashi J, Miyata S, Shimokawa H, Yasuda S.

2025-09-01

10.1093/europace/euaf184

Clinical impact of atrial fibrillation progression in patients with heart failure with preserved ejection fraction: A report from the CHART-2 Study

Tomohiro Ito, Takashi Noda, Kotaro Nochioka, Takashi Shiroto, Nobuhiko Yamamoto et al. (14 authors)

EP Europace2024-08-1610 citations

10.1093/europace/euae218

Temporal changes in left ventricular ejection fraction and their prognostic impacts in patients with Stage B heart failure.

Aoyanagi H, Nochioka K, Sakata Y, Miura M, Shiroto T, Abe R, Kasahara S, Sato M, Fujihashi T, Yamanaka S, Hayashi H, Sugimura K, Takahashi J, Miyata S, Shimokawa H, CHART-2 Investigators.

2020-02-155 citations

10.1016/j.ijcard.2020.02.040

Risk of de-novo heart failure and competing risk in asymptomatic patients with structural heart diseases.

Takada T, Sakata Y, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Suzuki K, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H, CHART-2 Investigators.

2020-02-065 citations

10.1016/j.ijcard.2020.02.015

Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment

Kota Suzuki, Takuya Oikawa, Kotaro Nochioka, Masanobu Miura, Shintaro Kasahara et al. (12 authors)

Arteriosclerosis Thrombosis and Vascular Biology2019-03-1432 citations

10.1161/atvbaha.119.312336

Prognostic Impact of Statin Intensity in Heart Failure Patients With Ischemic Heart Disease: A Report From the CHART‐2 (Chronic Heart Failure Registry and Analysis in the Tohoku District 2) Study

Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Kanako Tsuji et al. (14 authors)

Journal of the American Heart Association2018-03-1418 citations

10.1161/jaha.117.007524

Temporal Trends in Clinical Characteristics, Management and Prognosis of Patients With Symptomatic Heart Failure in Japan　– Report From the CHART Studies –

Ryoichi Ushigome, Yasuhiko Sakata, Kotaro Nochioka, Satoshi Miyata, Masanobu Miura et al. (16 authors)

Circulation Journal2015-01-01111 citations

10.1253/circj.cj-15-0514

Usefulness of combined risk stratification with heart rate and systolic blood pressure in the management of chronic heart failure. A report from the CHART-2 study.

Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H, CHART-2 Investigators.

2013-10-0126 citations

10.1253/circj.cj-13-0725

Urinary albumin excretion in heart failure with preserved ejection fraction: an interim analysis of the CHART 2 study.

Miura M, Shiba N, Nochioka K, Takada T, Takahashi J, Kohno H, Shimokawa H, CHART-2 Investigators.

2012-01-3145 citations

10.1093/eurjhf/hfs001

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Structural heart disease but without signs or symptoms of heart failure. * Structural heart disease with prior or current symptoms of heart failure. * Refractory heart failure requiring specialized interventions. * Patients with prior cardiovascular surgery or percutaneous coronary intervention and those who need such interventions.

Exclusion criteria

* Patients with age\<20 years old. * Patients who refused to participate.

Design outcomes

Primary

Measure	Time frame
All-cause death	At the time of registration and at least once a year thereafter
Non-fatal acute myocardial infarction	At the time of registration and at least once a year thereafter
Non-fatal stroke	At the time of registration and at least once a year thereafter
Heart failure requiring admission	At the time of registration and at least once a year thereafter

Countries

Japan

Outcome results