Infertility, Premature Ovarian Failure
Conditions
Keywords
poor responders, GnRH antagonist, GnRH agonist, flare up, short protocol
Brief summary
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation. Our hypothesis is that the antagonist protocol provides better IVF outcomes compared to the flare up protocol in this group of patients.
Detailed description
Poor responders are women who fail to respond effectively to the usual gonadotropin stimulation protocol applied in an IVF cycle. It seems that a diminished ovarian reserve is the principal factor of poor ovarian response. Several strategies have been proposed for the management of poor responders, including flare up GnRH agonist regimens and the GnRH antagonist, which presents a new hope in this group of patients. Comparisons: Poor responder patients (see inclusion criteria) commencing an IVF treatment cyle will receive ovarian stimulation treatment either using a GnRH antagonist (Ganirelix) or flare up agonist (Arvekap) protocol. Primary outcomes compared will be ongoing pregnancy rates in the two treatment groups.
Interventions
Sponsors
Eugonia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* regular menstrual cycle * 1 or more failed IVF attempts with poor response * 5 or fewer oocytes retrieved * FSH\>12 IU/l on day 3
Exclusion criteria
* PCOS * Normal responders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate per embryo transfer | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ovarian stimulation, total rFSH used, estradiol, LH and progesterone concentration on hCG day. | — |
| Number of mature oocytes retrieved. | — |
| Number of fertilised oocytes. | — |
Countries
Greece
Outcome results
None listed