Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00416299

Enrollment

100

Registered

2006-12-27

Start date

2007-05-31

Completion date

2007-08-31

Last updated

2009-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery

Keywords

Cardiac biomarker, cardiac surgery, elderly, postoperative complications, Patients aged 75 years or older undergoing cardiac surgery

Brief summary

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.

Detailed description

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

75 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion criteria

* positive cardiac troponin T test within the week before surgery * patients undergoing emergent procedures * patients with preoperative mechanical cardiac support * patients undergoing hemodialysis

Countries

Germany

Outcome results