Skip to content

Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis

The Effects of Knee Malalignment and Quadriceps Strengthening on the Adduction Moment in Individuals With Medial Knee Osteoarthritis

Status
Completed
Phases
Phase 2Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00414557
Enrollment
107
Registered
2006-12-21
Start date
2004-05-31
Completion date
2006-12-31
Last updated
2006-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Keywords

Musculoskeletal diseases, Joint diseases

Brief summary

To investigate the effects of quadriceps strengthening on the adductor moment in individuals with medial knee OA and whether quadriceps strengthening has a different effect on the adductor moment in individuals with and without knee malalignment

Detailed description

Although quadriceps strengthening is the cornerstone of physiotherapy management, recent evidence suggests that high quadriceps strength in patients with malaligned knees may increase OA progression. This study investigates the effects of quadriceps strengthening on the adduction moment in patients with medial knee OA with and without malalignment. 107 participants with and without varus knee malalignment were recruited and randomised into an exercise or a control group. Participants in the exercise group were taught five quadriceps strengthening exercises by a project physiotherapist to be performed five days a week for twelve weeks at home. The exercises were: 1. Quadriceps exercise over fulcrum using ankle weight 2. Straight leg raise exercise using ankle weight 3. Long arc knee extension exercise in sitting using ankle weight 4. Knee extension exercise with isometric hold at 60° knee flexion using ankle weight 5. Knee extension exercise with isometric hold at 60° knee flexion using an elastic band. Each exercise was performed at 2x10 repetitions for the first 2 weeks and 3x10 repetitions thereafter. Participants visited the physiotherapist 7 times at Week 1, 2, 3, 4, 5, 7 and 10. They were given the ankle weights and elastic band to bring home and instructed about the repetitions and weights to use by the physiotherapist, who also checked and progressed their exercises. The average duration of the physiotherapy sessions was 30 minutes. To monitor compliance, each participant was given an exercise instructions sheet and kept a training diary to record the exercises they had done. The control group received no intervention.

Interventions

Sponsors

Australian Physiotherapy Research Foundation
CollaboratorOTHER
United Pacific Industries
CollaboratorUNKNOWN
University of Melbourne
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE

Eligibility

Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Pain in the knee * Osteophytes on knee x-ray * Self-reported pain on the inner aspect of the study knee * Osteophytes in the medial compartment of the knee joint and * Medial joint space narrowing greater than lateral joint space narrowing on x-ray

Exclusion criteria

* Knee surgery within the previous 6 months * History of lower limb joint replacements * Systemic arthritic conditions such as rheumatic or psoriatic arthritis * Valgus knee deformity (\> 5º) * Inability to walk without the use of walking aids * Intending to start a lower limb strengthening program in the next 3 months * Seeking or currently receiving physiotherapy for OA knee

Design outcomes

Primary

MeasureTime frame
Adduction moment
Time points: 0 and 13 weeks

Secondary

MeasureTime frame
Quadriceps and hamstrings strength
Self-selected walking speed
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire
Physical function using stair climb test
Time points: 0 and 13 weeks
Dynamic balance using step test
Numerical rating scales for pain

Countries

Australia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026