Endotoxemia, Healthy, Type 2 Diabetes
Conditions
Keywords
Renal Plasma Flow, Endotoxemia, Type 2 diabetes
Brief summary
The purpose of the present protocol is to study whether endotoxemia will affect the renal blood flow in type 2 diabetics and healthy volunteers.
Detailed description
Many septic patients develop acute renal failure and the risk is higher in patients with diabetes. The pathogenetic mechanisms behind the development of acute renal failure in connection with sepsis is not completely understood. One among many possible explanations is a change in renal hemodynamics. However, it is still largely unknown what happens to the renal plasma flow during human sepsis. In this study we give endotoxin injection (0,3 ng/kg) to type 2 diabetics and healthy controls as an experimental model of sepsis. Renal plasma flow and glomerular filtration rate are measured by DTPA-renography 1 day before before and 1,25 and 6,5 hours after injection of endotoxin. Furthermore WBC, plasma-cytokines,VCAM-1/ICAM-1, endothelin-1, Thromboxane B2, angiotensin 2, renin and PAI-1 are measured on an hourly basis up to 8 hours after endotoxin injection.
Interventions
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * Type 2 diabetes
Exclusion criteria
* Renal failure * Heart failure * Lung disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal plasma flow, Glomerular filtration rate, Plasma cytokine content, Endotoxemia score, Plasma angiotensin II and renin content, Plasma thromboxane B2 content, Plasma PAI-1 content | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure, Heart rate, Oxygen saturation, Body temperature, | — |
Countries
Denmark
Contacts
Primary ContactAnne Sofie Andreasen, MD
Backup ContactBente K Pedersen, Professor
Outcome results
None listed