Elective Surgical Procedure, Colorectal Surgery
Conditions
Keywords
Systemic lidocaine, peridural lidocaine, perioperative analgesia, inflammation, Anesthesia
Brief summary
The purpose of this study is to comparing effects of intravenously (IV) administered lidocaine to effects of epidurally (ED) administered lidocaine in patients undergoing elective colorectal surgery
Interventions
DRUGlidocaine
administration of lidocaine intravenously or epidural or administration of placebo
DRUGNaCl 0,9%
Administration of placebo i.v.
Sponsors
International Anesthesia Research Society (IARS)
University Hospital Muenster
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* elective colorectal surgery
Exclusion criteria
* ASA \> 3 * history of anti-inflammatory therapy * history of inflammatory bowl diseases * history of chronic pain treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| length of postoperative hospital stay | end of hospital stay |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine levels perioperative | before surgery and 4 hours, 2 and 4 days after surgery |
| Bowel motility perioperative | days after surgery |
| Length of PACU stay | end of PACU stay |
| Hyperalgesia perioperative | postoperative day 2, 4, 8, end of hospital stay and follow-up |
| Incidence of wound healing disturbances | within 4 weeks after surgery |
| Postoperative Analgesia | until end of hospital stay |
| Cognitive function perioperatively | before surgery, one and four days after surgery, at end of hospital stay and follow-up |
Countries
Germany
Outcome results
None listed