Alzheimer's Disease
Conditions
Brief summary
The aim of the protocol is to study the resting brain activation profile of 3 groups of people, using a new fMRI procedure, called fMRI-SAM. fMRI-SAM will be applied to 25 Alzheimer's disease (AD) patients, 25 patients suffering from amnestic - mild cognitive impairment (MCI) - a clinical picture which may be a prodromal form of AD - and 60 healthy controls. The first analysis of the data will search differences of brain activation profiles between the 3 groups. In the second step, the investigators will study the predictive value of fMRI-SAM to detect MCI patients who will later convert to AD.
Interventions
PROCEDUREfMRI to detect MCI patients who will convert to Alzheimer's disease
There is a fMRI to be realized in the 3 arms. No drug is administered
Sponsors
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Alzheimer's disease of mild to moderate severity (25 patients) * Amnestic MCI patients (25 patients) * 55-75 year-old patients
Exclusion criteria
* Any other cause of dementia for AD patients * Any stroke * Any disease with a negative vital prognosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing fMRI data between 3 groups of subjects: MCI, Alzheimer's disease and normal subjects | 1, 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Follow-up of MCI patients at 6, 12 and 18 months to detect a conversion to Alzheimer's disease | Prediction of Alzheimer's disease on fMRI data |
Contacts
PRINCIPAL_INVESTIGATORFrancois Sellal, MD
Hôpitaux Universitaires de Strasbourg
Outcome results
None listed