Cognitive/Functional Effects, Colorectal Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Conditions
Keywords
cognitive/functional effects, long-term effects secondary to cancer therapy in adults, recurrent colon cancer, stage I colon cancer, stage II colon cancer, stage III colon cancer, stage IV colon cancer
Brief summary
RATIONALE: Learning about the long-term effects of chemotherapy and radiation therapy on brain function may help doctors plan cancer treatments. PURPOSE: This clinical trial is looking at the neurological effects of chemotherapy and radiation therapy in patients with colon cancer.
Detailed description
OBJECTIVES: Primary * Identify the nature and long-term ramifications of CNS injury as a result of cancer treatment in patients with colon cancer. Secondary * Analyze differences in cognitive measures and MRI data in these patients. * Correlate MRI measures with cognitive performance in these patients. OUTLINE: Patients undergo cognitive performance assessment and MRI. PROJECTED ACCRUAL: A total of 42 patients will be accrued for this study.
Interventions
PROCEDUREcognitive assessment
PROCEDUREmagnetic resonance imaging
PROCEDUREmanagement of therapy complications
Sponsors
National Cancer Institute (NCI)
University of Arizona
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of colon cancer * Received chemotherapy and radiotherapy for colon cancer PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nature and long-term ramifications of CNS injury as a result of cancer treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in cognitive measures and MRI data | — |
| Relationship between MRI measures and cognitive performance | — |
Countries
United States
Outcome results
None listed