Body Composition, Inflammation
Conditions
Brief summary
prospective longitudinal measurements of nutritional status parameters (body composition by BIA, anthropometry and biochemical indexes), inflammatory response (CRP, inflammatory cytokines (IL-1, IL-6, IL-10),IGF-1, leptin and NOx blood levels) and morbidity and mortality data collection over 2 year period in patients receiving chronic hemodialysis.
Interventions
None listed
Sponsors
Assaf-Harofeh Medical Center
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Male or female, age \> 18 years, in chronic hemodialysis treatment at least 3 months * Stable and adequate hemodialysis treatment three months prior to participation in study as defined by Kt/V \> 1.2 and/or hemodialysis performed 4 hours 3 times weekly * Patients with normal hydration status (edema-free), with no neuro-muscular diseases * Informed consent obtained before any trial-related activities
Exclusion criteria
* Patients with edema, pleural effusion or ascites at their initial assessment * Patients with active malignant disease or liver cirrhosis * Patients with neuro-muscular diseases * Patients on chronic treatment with steroids on doses \> 10 mg/day Prednisone (or equivalent) * Patients treated with immunosuppressive agents * Patients suffering from * Acute vasculitis * Severe systemic infections * Heart failure (NYHA class III-IV) * The receipt of any investigational drug within 1 month prior to initiating of this study
Countries
Israel
Outcome results
None listed