Acute Myocardial Infarction
Conditions
Brief summary
To determine whether the application of ventricular pacing can protect the human heart from damage resulting from a myocardial infarction
Detailed description
To determine whether the application of ventricular pacing can protect the human heart from damage resulting from a myocardial infarction
Interventions
DEVICETemporary RV VVI pacing
temporary pacing at the onset of revascularisation
Sponsors
Guidant Corporation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of acute myocardial infarction, requiring PCI within 2 to 6 hours following symptoms * Total occlusion of a coronary artery with reference vessel diameter \>or= 3mm
Exclusion criteria
* Thrombolitics * Severe bradycardia requiring cardiac pacing * Previous PCI or CABG * Recent stroke or CV surgery * Recent major surgery or trauma * Clinical and hemodynamic unstability * Implanted CRM device * Evidence of previous MI * Diabetes using rosiglitazone or other fibrates * Permanent AF * Mechanical tricuspid valve * Pregnancy * Exclusion for MRI * Incapability of participating in exercise test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infarct size (area under the curve of creatine kinase) at baseline compared with MRI at 4 months and at 12 months | 4 & 12 months |
Countries
Netherlands
Outcome results
None listed