Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry

Relationship Between Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry In Healthy Subjects

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00409110

Enrollment

Registered

2006-12-08

Start date

2006-01-31

Completion date

2011-08-31

Last updated

2011-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Ocular Pulse Amplitude, Dynamic Contour Tonometry, Pulsatility Index, Choroidal Laser Doppler Flowmetry, Finometer

Brief summary

This study intends to investigate the relationship between choroidal blood flow and ocular pulse amplitude (OPA).

Detailed description

One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

45 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subjects should present no history of ocular diseases, of current topical medication, or of drug or alcohol abuse. Furthermore, a best corrected visual acuity above 20/25 in both eyes, lack of pathological findings upon a slit-lamp examination and dilated direct fundoscopy, and an IOP \< 21 mmHg in both eyes will be required.

Exclusion criteria

* History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis. * History of ocular trauma or intraocular surgery. History of infection or inflammation within the past 3 months. * History and clinical evidence for other retinal disease such as age-related degeneration, or diabetic retinopathy.

Design outcomes

Primary

Measure	Time frame
An association of OPA with the LDF pulsatility index	30 seconds

Secondary

Measure	Time frame
An association of OPA with the systemic blood pressure values	30 seconds
An association of OPA with mean intraocular pressure	30 seconds

Countries

Switzerland

Outcome results