Coronary Artery Disease, Hypercholesteremia
Conditions
Keywords
Lipitor, atorvastatin, Hypercholesteremia, yellow coronary plaque
Brief summary
To evaluate the efficacy of intensive lipid-lowering therapy with Lipitor on the changes of characteristics of yellow coronary plaque in subjects with hypercholesteremia accompanying coronary artery disease
Interventions
DRUGatorvastatin, Lipitor
Sponsors
Astellas Pharma Inc
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* Patients with hypercholesteremia * The indication of coronary angiography, coronary angioscopy and intravascular ultrasound are expected
Exclusion criteria
* Patients who has current administration of Lipitor or history of discontinued administration of Lipitor * Acute cardiac infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in plaque characteristics as observed by coronary angioscopy | — |
| (the amount of yellow plaque and grade shall be determined by the coronary angioscopic findings evaluation committee) | — |
| Changes in the volume and the echogenicity as observed by intravascular ultrasound | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of change in serum lipid level | — |
| Changes in the surface character and size of plaque as observed by coronary angioscopy (determined by the angioscopic findings evaluation committee) | — |
Countries
Japan
Outcome results
None listed