Corneal Barrier Function With Multi-Purpose Solutions

Comparison of Human Corneal Barrier Function With Three Marketed Multi-Purpose Solutions

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00407238

Enrollment

Registered

2006-12-04

Start date

2006-11-30

Completion date

2007-03-31

Last updated

2007-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contact Lens Care

Keywords

barrier function, multi-purpose solutions, silicone hydrogel contact lenses

Brief summary

The purpose of this study is to evaluate the effect on epithelial barrier function of three emarketed multi-purpose solution applied to the human eye with hydrogel lenses as during normal regimen use.

Detailed description

Interventions

DEVICEMulti-purpose solutions (polyquaternium-1 and PHMB)

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adapted daily soft contact lens wearers, at least 18 years of age, vision correctable to 20/40

Exclusion criteria

* Ocular or systemic allergies, abnormalities of the cornea, active ocular infection, prior keratorefractive surgery, use of ocular medications

Design outcomes

Primary

Measure	Time frame
Ratio of fluorescein dye penetration rate of test eye vs. control	—

Secondary

Measure	Time frame
Corneal fluorescein staining	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026