Aspirin Use and Postoperative Bleeding From Dental Extractions in a Healthy Population

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00405613

Enrollment

Registered

2006-11-30

Start date

2003-05-31

Completion date

2005-12-31

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding Complication

Keywords

Aspirin, Bleeding, Clinical Trial, Dental Extraction

Brief summary

The purpose of this study is to determine if aspirin is associated with bleeding complications following a single tooth extraction

Detailed description

Aspirin is a common chronically administered preventive treatment for cardiovascular disease, but is often discontinued prior to invasive dental procedures because of concern of bleeding complications. As the goal of aspirin is often to prevent MI and stroke, the risk of these CVD outcomes with discontinuation of aspirin must be weighed against the perceived adverse event of bleeding during or following an invasive dental procedure with continuation of aspirin. The current study is a randomized controlled trial evaluating bleeding complications of aspirin vs. placebo in healthy patients schedule for a single tooth extraction.

Interventions

DRUGAspirin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * Require a simple tooth extraction

Exclusion criteria

* Use of previous aspirin or NSAID

Design outcomes

Primary

Measure	Time frame
Oral bleeding time	—

Secondary

Measure	Time frame
Report of bleeding at phone follow-up at 3-7 (first follow-up) and 40-55 hours (second follow-up)	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026