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Effects of OA Decompression on the Autonomic Nervous System

Effects of OA Decompression on Activity of the Autonomic Nervous System

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00403936
Enrollment
100
Registered
2006-11-27
Start date
2005-04-30
Completion date
2005-05-31
Last updated
2010-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Tension

Keywords

osteopathic manipulation, autonomic nervous system

Brief summary

This study was designed to determine whether a simple manipulative technique of relaxing the tissues of the occipito-atlantal junction in the neck had any effect on the activity of the sympathetic or parasympathetic nervous system. Subjects were dark adapted then measures of pupillary activity, reflecting autonomic nervous system activity were taken before and after treatment. The study hypothesis was that thet treatment technique would have no effect on the pupillary measures, hence indicating no effect on autonomic system activity.

Detailed description

This study was a within subjects/crossover design in which each subject received the treatment and served as his/her own control. 100 subjects were recruited from the student/staff population of the university, were 18 y/o or older with no condition affecting pupillary activity. Pupillary activity was measured with a PLR100 pupillometer and included pupillary diameter, pupillary response latency, maximum constriction velocity and maximum redilation velocity. Subjects were adapted to a dim light environment, measures taken, treatment given at either third or fourth time period and measures retaken. The study was approved by the NSU IRB. Subject numbers were sufficient to have statistical power to find an effect. The study found an effect of treatment on maximum size, showing a decrease with treatment.

Interventions

PROCEDUREOA decompression manipulation

Sponsors

Nova Southeastern University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* 18 y/o * Normal accommodation and pupillary response * Willing to undergo osteopathic manipulation

Exclusion criteria

* Active ocular or systemic disease * Neurologic disease that would alter pupillary response * Chronic pain syndromes of head or neck * Pregnant * Brain injury * Taking medications that would alter autonomic tone

Design outcomes

Primary

MeasureTime frame
pupillary diameter
pupillary latency
pupillary constriction velocity
pupillary redilation velocity

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026