Hematopoietic Stem Cell Transplantation
Conditions
Keywords
Cancer, Exercise, Health Related Quality of Life, PBSCT
Brief summary
The proposed study in an inception cohort of patients with hematological malignancies treated with PBSCT is designed to evaluate the effects of a physical exercise intervention on muscular-skeletal, physical activity and quality of life outcomes.
Detailed description
Peripheral Stem Cell Transplantation is a frequently used therapy option to increase survival in hematological and lymphatic malignancies. These malignancies and their treatment are associated with numerous physical and psychological symptoms and severe side effects. Physical exercise has been proposed as a promising strategy for the treatment of some of these physical and psychological complaints, and various exercise interventions are currently available after cancer treatment. To date, promising preliminary results concerning exercise programs in PBSCT recipients were published with limited sample size populations. Results of musculoskeletal outcomes in PBSCT recipients after cancer treatment are lacking.
Interventions
BEHAVIORALAmbulatory Physical Exercise Program
supervised exercise, 2 x / week
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Status after high-dose chemotherapy following Hematopoietic Stem Cell Transplantation * Willing to enter a physical exercise program * Good understanding of the German language * Written informed consent
Exclusion criteria
* Uncontrolled cardiovascular disease and myocardial infarction in the previous six months * Uncontrolled hypertension * Uncontrolled thyroid disease * Uncontrolled diabetes * Diagnosis of depression before entering the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| and Health Related Quality of Life: (Physical function subscale of the EORTC-QLQ-C30 questionnaire). | Baseline -3 months - 6 months |
| Musculoskeletal performance | Baseline -3 months - 6 months |
| Knee extension strength | Baseline -3 months - 6 months |
| Grip Strength | Baseline -3 months - 6 months |
| 6 minute walk test | Baseline -3 months - 6 months |
| 15-meter walking speed | Baseline -3 months - 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Self-reported fatigue | Baseline -3 months - 6 months |
| Self-reported and objectively assessed physical activity | Baseline -3 months - 6 months |
| Whole body composition | Baseline -3 months - 6 months |
| Haemotological values: e.g Hemoglobin | Baseline -3 months - 6 months |
| Role-,cognitive-,emotional-,social-,symptom scales and the global health and quality of life scale of the EORTC-QLQ-C30 Health Related Quality of Life questionnaire. | Baseline -3 months - 6 months |
Countries
Netherlands, Switzerland
Outcome results
None listed