Alcohol Abuse, Hepatitis B, Hepatitis C, Iron Overload, Metabolic Syndrome X
Conditions
Keywords
Magnetic resonance imaging, Hepatic iron, Steatosis
Brief summary
Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most reliable method is histological or biochemical assessment from a liver biopsy. Because liver biopsy is an invasive procedure, imaging methods have been developed to detect and quantify hepatic iron content. The aim of the study is to use a simplified magnetic resonance imaging (MRI) technique to quantify simultaneously iron and fat contents in the liver and to compare the results to the quantification obtained biochemically.
Detailed description
Iron excess is increasingly regarded as an important cofactor in the morbidity attributed to many disorders. Assessment of body iron stores by measurement of serum ferritin concentrations has poor specificity and the most reliable method is histological or biochemical assessment from a liver biopsy. Because liver biopsy is an invasive procedure, imaging methods have been developed to detect and quantify hepatic iron content. The aim of the study is to use a simplified magnetic resonance imaging technique to quantify simultaneously iron and fat contents in the liver and to compare the results to the quantification obtained biochemically. Patients who need a liver biopsy will be proposed to be enrolled in the study. A magnetic resonance (MR) study will be performed using breath-hold gradient echo sequences with a single echo and a new multiple-echo gradient-echo sequence. Liver and muscle MR signal will be quantitatively determined and compared to biochemical assessment of liver iron concentration and steatosis quantification.
Interventions
DEVICEMagnetic resonance imaging multiecho gradient-echo sequence
Breath-hold gradient echo sequences with a single echo and a new multiple-echo gradient-echo sequence
Sponsors
Ministry of Health, France
Rennes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults over 18, * Planned liver biopsy (or liver biopsy within 2 months before inclusion) for one of these indications: suspicion of liver iron overload, metabolic syndrome, hepatitis B or C, alcohol abuse. No change in diet, transfusions or iron depletion must have occur between the liver biopsy and the MRI. * Having given a written informed consent.
Exclusion criteria
* Non cooperating patient, * Patient with dyspnea, * Patient with contra-indication to MR imaging (pace-maker, heart valve,...).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver to muscle signal intensity ratio and T2* calculation versus liver iron concentration | during examination |
Secondary
| Measure | Time frame |
|---|---|
| Influence of the antenna for the multiecho gradient-echo sequence | during examination |
| Difference between in-phase and out-phase T2* calculation versus liver fat concentration | during examination |
| Correlation between biochemical and MRI quantification of liver iron | during examination |
| Correlation between participating centers | during examination |
| Reproducibility of the multiecho gradient-echo sequence | during examination |
Countries
France, Spain
Outcome results
None listed