Abnormalities of B Lymphocytes During Systemic Lupus

Phenotypic Characteristics and Transcriptomas of B Lymphocytes During Non Active Systemic Lupus Erythematosus

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00401141

Enrollment

Registered

2006-11-17

Start date

2004-04-01

Completion date

2009-05-01

Last updated

2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic Lupus Erythematosus

Keywords

Systemic lupus, B lymphocytes, transcriptomas

Brief summary

Previous experimental data strongly suggest that B lymphocytes have intrinsic abnormalities during lupus in mice spontaneously affected by the disease. This study tries to define these abnormalities by looking at the gene expression profile of purified B lymphocytes from patients with non active systemic lupus , compared with the gene expression profile of purified B lymphocytes from healthy donnors.

Interventions

PROCEDUREBlood samples

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* non active systemic lupus

Exclusion criteria

* immunosuppressive drugs * more than 10 mg of prednisone per day

Countries

France

Contacts

STUDY_DIRECTORJean-Louis Pasquali, MD

Hôpitaux Universitaires de Strasbourg

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 9, 2026