Chromogranin-A-Derived Peptides and Periodontitis in Diabetic Patients

Chromogranin-A-Derived Peptides in the Gingival Crevicular Fluid and the Saliva of Diabetic Patients With or Without Periodontitis

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00399620

Enrollment

Registered

2006-11-15

Start date

2008-03-31

Completion date

Unknown

Last updated

2009-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis and Diabetitis

Keywords

Periodontitis, Diabetes, Gingival crevicular fluid, GCF, Saliva, Chromogranin, Electrophorèse, Western Blot, RT-HPLC

Brief summary

Periodontitis is a chronic disease of the supporting tissue of the teeth, characterized by bleeding and inflamed gingival, resorption of alveolar bone. This disease has a significant impact of the quality of life as the teeth become progressively mobile and may fall out spontaneously if no treatment is provided. Periodontal disease has been cited as the sixth complication of diabetes mellitus.Chromogranins / secretogranins are a family of proteins present in nervous endocrine and immune cells, released with catecholamines during stress situations. Chromogranin A (CGA) is the major member of this family.The aim of this study is to determine the level of CGA and its derived peptides in the gingival crevicular fluid (GCF) of health or diabetic patients with and without periodontitis.Then, we want to determine the antimicrobial activity of these peptides.

Interventions

PROCEDUREGingival crevicular fluid samples (this procedure is added to the subject usual medical follow-up).

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients from 20 to 80 years old * A minimum of 10 teeth * Healthy volunteers or diabetic patients with or without periodontitis

Exclusion criteria

* a course of antibiotics * a fungicidal therapy * a corticotherapy * a hormone therapy * a pregnancy * persons under guardianship

Countries

France

Contacts

Primary ContactMartine Soell, MD

martine.soell@chru-strasbourg.fr33 6 74 86 67 36

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026