OCD
Conditions
Brief summary
Testing the efficacy of the SNRI medication Duloxetine for treating OCD patients who did not respond to SSRI
Interventions
DRUGDuloxetine
Sponsors
Sheba Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* OCD as main diagnosis according to DSM-IV * Age 18 to 65 * Men and women * YBOCS score is 18 or more, or 12 or more in case of only obsessions
Exclusion criteria
* Patients treated with Duloxetine, currently or in the past * Patients having comorbid schizophrenia or psychotic disorder or bipolar disorder Patients with substance abuse disorder in the last 6 months Patients who were suicidal or did serious suicide attempt in the last year Pregnant or lactating women, or woman of childbearing potential, which is not using adequate contraception Patients with neurologic disturbance or disorder Patients with serious or imbalanced medical condition Patients with allergic response to SSRI or duloxetine Patients who started new treatment (CBT or pharmacology) in less than 3 months
Countries
Israel
Outcome results
None listed