Metastatic Colorectal Cancer
Conditions
Keywords
Metastatic colorectal cancer, tailored treatment, genetic markers, gene polymorphism, chemotherapy
Brief summary
To compare the response rate of single agent chemotherapy in advanced colorectal cancer given as standard treatment versus tailored treatment in a randomised phase III trial.
Detailed description
The TS and MTHFR polymorphism has been investigated in a new study based on analysis of normal tissue. The results indicated that protein with a 3/3 TS polymorphism or a MTHFR T polymorphism had a significantly higher response rate and a longer time to progression than the other groups when treated with bolus 5-FU. Capecitabine is metabolised to 5-FU through a number of enzymatic steps. It is the first rationally designed drug that is based upon the high concentration of thymidine phosphorylase (TP) in many human tumors compared to normal tissue. TP is the last step in the conversion of capecitabine to 5-FU and seems to be the limiting factor for the activation. Capecitabine may to some extent mimic continues 5-FU infusion as opposed to bolus 5-FU. A number of small investigations have indicated that patients with 2R/2R TS polymorphism have a higher response rate than heterozygous patients. The TS and MTHFR polymorphism analysis can easily be performed on sputum, which means an easy collection and sending of the samples. At present single agent chemotherapy is based on three drugs (5-FU, capecitabine, and Irinotecan) with almost the same overall activity. It seems rational to investigate if improvement can be obtained by tailoring the treatment according to gene polymorphism.
Interventions
DRUGCapecitabine, Irinotecan, 5-Fluorouracil+Calciumfolinat
Sponsors
Vejle Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Metastatic colorectal cancer * Histopathological verification of the primary tumor * Measurable disease according to RESIST criteria * Single agent chemotherapy indicated * Performance status \>=2 * Age \>= 60 years * Life expectancy \> 3 months * Adequate liver and kidney function as evaluated by bilirubin \<= 3 times of normal upper limit, ALAT \<= 3 times upper normal limit (\<= 5 times upper normal limit in case of liver metastases), serum creatinine \<= 1.5 times normal upper limit. * ANC \>=1.5 x 109/l and platelets \>= 100 x 109/l * Informed consent
Exclusion criteria
* Patients with CNS metastases * Other malignant disease within the last 5 years except for non-melanoma skin cancer and carcinoma in situ of cervix uteri * Previous chemotherapy for metastatic disease * Adjuvant chemotherapy \< 6 months before inclusion * Patients with previous major toxic or allergic reaction to the protocol drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point is | — |
| Response according to RECIST criteria. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary end points are | — |
| Progression free survival | — |
| Overall survival | — |
| Toxicity | — |
Countries
Denmark
Outcome results
None listed