Cerebrovascular Accident
Conditions
Brief summary
The purpose of the study is to determine whether methylphenidate facilitates so called short-term plasticity as measures with transcranial magnetic stimulation, in patients with stroke.
Detailed description
Stroke patients are to be examined with transcranial magnetic stimulation (TMS) before and after a short training session. TMS will be used to demonstrate changes in cortical excitability (motor threshold) and intracortical inhibition and facilitation. The effect of methylphenidate on baseline TMS measures will be evaluated as well as the effect on training induced changes in TMS measures (by comparing baseline and posttraining measures). The patients will be trained on two separate occasions, to compare the effect of Methylphenidate to placebo.
Interventions
DRUGMethylphenidate
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Less than two months after first stroke. * Moderate to light hand paralysis * Measurable MEP in the abductor pollicis brevis muscle * Able to read and understand the written information * Signed informed consent
Exclusion criteria
* Epilepsy * Glaucoma * Hyperthyroidism * Cardiac arrythmia * Known heart disease or angina. * Metal implants * Pacemaker * Pregnancy * Diastolic BP\>100 mmHg * In treatment with MAO-inhibitor, SSRIs og Ritalin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Training induced changes in Short interval Intracortical Inhibition (SICI). | — |
| Training induced changes in Intracortical facilitation (ICF) | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline SICI, ICF, and motor threshold compared between methylphenidate and Placebo | — |
Countries
Denmark
Outcome results
None listed