Diabetes, Heart Disease
Conditions
Brief summary
High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.
Interventions
DRUGrHDL
Sponsors
Baker Heart Research Institute
Bayside Health
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Aged 18 - 65 years * Free of overt coronary disease * Body mass index \<35 kg.m-2 * Fasting plasma glucose \> 7 mmol/L-1 * No major illness
Exclusion criteria
* Unable to give informed consent * Smokers * Abnormal LFT, U&E, FBE or creatinine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic parameters | — |
Countries
Australia
Outcome results
None listed