Bronchoscopy
Conditions
Brief summary
Passing a bronchoscope through the airways frequently causes a stress response even though patients are sedated. This stress response is usually an increase in pulse and blood pressure, which may have undesirable effects on the heart and circulation. We plan to give patients labetalol (a beta blocker which reduces pulse and blood pressure) in addition to normal sedation, to patients undergoing bronchoscopy in our department.
Interventions
DRUGLabetalol 10mg iv
Sponsors
Rabin Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients over 18 years old undergo fiberoptic bronchoscopy in our unit
Exclusion criteria
* inability or refusal to give informed consent * bronchoscopy through an artificial airway * intolerance or allergy to the study drug * bradycardia (HR\<60/min) or hypotension (systolic BP \<100) at screening * pregnancy, * concomitant treatment with diltiazem or verapamil * intention to use propofol as the sedative agent for bronchoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart Rate | — |
| Systolic Blood Pressure | — |
| Diastolic Blood Pressure | — |
| Rate pressure product (HR*SBP/100) | — |
Countries
Israel
Outcome results
None listed