Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00394108

Enrollment

Registered

2006-10-31

Start date

1999-08-31

Completion date

2002-07-31

Last updated

2007-12-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CABG-Patients

Brief summary

The study aims to evaluate neuropsychological disorders in CABG patients. Measurements are performed 1 day before, 6 days, 6 months and 3-5 years after the surgery. The relation with cerebrovascular reactivity and embolic load (measured by transcranial Doppler Ultrasonography) is evaluated. Two surgery techniques (on- and off-pump CABG) are compared.

Interventions

PROCEDUREDetermination of neuropsychological status

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 69 Years

Healthy volunteers

Inclusion criteria

* CABG-patients (not urgent) * \< 70 years old * Righthanded

Exclusion criteria

* Neurological or psychiatric disease * Psychoactive medication * Valve operation

Design outcomes

Primary

Measure	Time frame
Neuropsychological status	after 6 days, 6 months and 3-5 years

Secondary

Measure	Time frame
Relation with intra-operative embolic load	—

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026