A Randomized, Control Trial for Preinduction Cervical Ripening

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00393731

Enrollment

540

Registered

2006-10-30

Start date

2004-01-31

Completion date

2007-08-31

Last updated

2008-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Labor, Induced

Keywords

labor, induction, misoprostol, oxytocin

Brief summary

The goal of this study is to compare the vaginal delivery rates in women undergoing induction of labor with an unripe cervix between oxytocin induction alone and preinduction cervical ripening with prostaglandin El (misoprostol). Secondary goals are to measure and compare the time intervals to delivery between the two methods.

Interventions

DRUGMisoprostol

DRUGoxytocin

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

FEMALE

Inclusion criteria

* Women that are hospitalized for induction of labor that have a Bishop's score \<5 * singleton gestation * cephalic presentation * 24 weeks gestational age

Exclusion criteria

* Prior uterine surgery * malpresentation * placenta previa or abruption * clinically suspected or diagnosed intra amniotic infection * genital HSV infection * multiple gestation * premature rupture of the membranes * active labor * maternal/fetal conditions that may preclude labor induction in the opinion of the investigators

Design outcomes

Primary

Measure	Time frame
Vaginal Delivery rates	—

Secondary

Measure	Time frame
Time interval to delivery	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026