Follicular Lymphoma
Conditions
Keywords
follicular lymphoma, non-Hodgkin lymphoma, Fludarabine, Cyclophosphamide, Rituximab, combination, immuno-chemotherapy, relapsed
Brief summary
Purpose of this study was to assess the safety profile and the anti-lymphoma activity of the FC+R combination.
Detailed description
The natural history of follicular lymphomas is characterized by a high initial response rate to chemotherapy followed invariably by relapse, with subsequent remissions of progressively shorter duration. The majority of patients eventually die of their disease. As yet, there is no gold standard for the treatment of newly diagnosed or relapsed advanced FL.Rituximab(R) has been shown to be a highly effective agent in the treatment of FL, either alone or in combination with chemotherapy. The ability of R to sensitize indolent lymphoma derived cell lines to cytotoxic chemotherapy agents has been demonstrated. Furthermore, fludarabine (F) may also sensitize cells to the effects of R. Cyclophosphamide (C) and F have shown in vivo synergistic activity. In view of the single agent activity and demonstrated synergy between C and F, and between F and R, we evaluated FC+R in previously treated patients with advanced FL. The primary aim of this study was to assess the safety profile and clinical activity of the FC+R combination. The secondary goal was to evaluate the ability of the treatment to convert bone marrow Bcl2 positivity such that patients achieved molecular remissions.
Interventions
DRUGrituximab
DRUGrituximab,fludarabine, cyclophosphamide
Sponsors
Gruppo Italiano Studio Linfomi
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* histologically documented WHO grade 1-2 ,CD20+,follicular lymphoma * relapsed Follicular lymphoma * stage III or IV disease * Stage II patients are eligible if they present with B symptoms or bulky disease * to have a need for therapy in the opinion of treating clinician * measurable disease * expected survival of 6 months or more * age 18 to 70 years * to have undergone \< 3 lines of chemotherapy * performance status of 0 to 2
Exclusion criteria
* known HIV infections * Known Hepatitis B or C * CNS lymphoma * previous malignancies, or cardiac, renal, hepatic, or respiratory failure * Pregnant or lactating women and patients of child bearing potential unless using birth control measures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Toxicity during the treatment period | — |
| Efficacy evaluated in terms of complete and partial response 1 month after the end of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy evaluated in terms of molecular response ( bone marrow Bcl2 negativity after treatment) | — |
Countries
Italy
Outcome results
None listed