Non-melanoma Skin Cancer
Conditions
Brief summary
The purpose of this study is to evaluate whether selenium and/or vitamin E are effective in preventing non-melanoma skin cancers.
Interventions
DIETARY_SUPPLEMENTSelenium
200 ug Selenium daily
DIETARY_SUPPLEMENTvitamin E
100 mg Vitamin E daily
Sponsors
Columbia University
Dartmouth-Hitchcock Medical Center
International Centre for Diarrhoeal Disease Research, Bangladesh
University of Chicago
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Manifest arsenic skin lesions (melanosis, leucomelanosis, or keratosis) * Aged 25 to 65 years * Permanent resident of study area
Exclusion criteria
* Pregnancy * Clinically too ill (enlarged spleen or liver) * Presence of gangrene * Cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin Cancer | Incidence during the 6-year study period |
Secondary
| Measure | Time frame |
|---|---|
| Mortality | Occurrence during the 6-year study period |
| Diabetes | Incidence within 6-year study period |
Countries
Bangladesh
Outcome results
None listed