Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00392275

Enrollment

Registered

2006-10-25

Start date

2002-11-30

Completion date

2006-05-31

Last updated

2013-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract

Keywords

Cataract, Aqueous absorption, Funtioning Filtering Blebs

Brief summary

Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.

Detailed description

The purpose of this study is to assay human aqueous for concentrations of ofloxacin, ciprofloxacin and levofloxacin after topical or combined topical and oral administration in eyes with filtering blebs.

Interventions

DRUGOfloxacin 0.3%

DRUGCiprofloxacin 0.3%

DRUGLevofloxacin 0.5%

DRUGOfloxacin 400mg

DRUGCiprofloxacin 400mg

DRUGLevofloxacin 250mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* All patients with functioning filtering blebs will be evaluated prospectively for inclusion

Exclusion criteria

* Any subject who is already scheduled to have cataract surgery performed will qualify for participation with the exception of the following

Design outcomes

Primary

Measure	Time frame
Aqueous levels of antibiotics	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026