Bipolar Disorder
Conditions
Keywords
bipolar disorder, magnetic resonance imaging, white matter, diffusion tensor imaging, children, adolescents
Brief summary
Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.
Detailed description
We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls.
Interventions
None listed
Sponsors
American Academy of Child Adolescent Psychiatry.
Eli Lilly and Company
Cambridge Health Alliance
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 13 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 6 to 13 * Male or female * Right-handed
Exclusion criteria
* IQ less than 70 * Learning disabilities * History of autism, schizophrenia, anorexia or bulimia nervosa * Substance abuse * Claustrophobia * Metal in body * Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional anisotropy in brain white matter | Baseline |
Countries
United States
Outcome results
None listed