Choroidal Neovascularization Secondary to Pattern Dystrophy
Conditions
Keywords
Pattern Dystrophy, Choroidal Neovascularization, Intravitreal Avastin Injection
Brief summary
The natural history of subfoveal CNV secondary to Pattern Dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter. Photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated.
Detailed description
Diagnosis of Pattern Dystrophy Diagnosis of subfoveal CNV Intravitreal injection of avastin (1.25 mg) in operating room under sterile condition. Retreatment on the basis of the detection of disease progression and of lack of central retinal thickness reduction on OCT.
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* diagnosis of RPD (hyperpigmented yellowish-greyish network, other family members sharing RPD, normal electroretinogram and normal/subnormal electrooculogram) * classic or occult CNV involving the foveal avascular zone's geometric centre
Exclusion criteria
* conditions other than RPD * intraocular surgery or capsulotomy within the last 2 or 1 months * pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of eyes with <15 letter loss (approximately <3 lines) at 6-month examination compared with the baseline value | — |
| numeber of eyes with <15 letter loss at 12-month examinations, compared with the baseline value. | — |
Secondary
| Measure | Time frame |
|---|---|
| CNV progression | — |
| number of injections. | — |
Countries
Italy